Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243849
Type: Artigo de periódico
Title: Neutrophil Gelatinase-associated Lipocalin Concentration In Vaginal Fluid: Relation To Bacterial Vaginosis And Vulvovaginal Candidiasis
Author: Beghini
Joziani; Giraldo
Paulo C.; Linhares
Iara M.; Ledger
William J.; Witkin
Steven S.
Abstract: Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms. We evaluated whether NGAL was present in vaginal fluid and whether concentrations were altered in women with bacterial vaginosis (BV) or vulvovaginal candidiasis (VVC). Methods: Vaginal secretions from 52 women with VVC, 43 with BV, and 77 healthy controls were assayed by enzyme-linked immunosorbent assay for NGAL and for concentrations of l-lactic acid. Results: The median concentration of NGAL in vaginal fluid was significantly higher in control women (561 pg/mL) than in women with BV (402 pg/mL; P = .0116) and lower in women with VVC (741 pg/mL; P = .0017). Median lactic acid levels were similar in controls (0.11 mmol/L) and women with VVC (0.13 mmol/L) and were lower in women with BV (0.02 mmol/L; P < .0001). The NGAL and lactic acid concentrations were highly correlated (P < .0001). Conclusion: A decrease in Lactobacilli and/or lactic acid plus the absence of leukocytes results in lower vaginal NGAL levels that might facilitate the growth of bacteria associated with BV.
Subject: Epithelial-cells
Lactic-acid
Infection
Iron
Country: THOUSAND OAKS
Editor: SAGE PUBLICATIONS INC
Citation: Neutrophil Gelatinase-associated Lipocalin Concentration In Vaginal Fluid: Relation To Bacterial Vaginosis And Vulvovaginal Candidiasis. Sage Publications Inc, v. 22, p. 964-968 AUG-2015.
Rights: embargo
Identifier DOI: 10.1177/1933719115570914
Address: http://rsx.sagepub.com/content/22/8/964
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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