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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleProduction Of Vegetable Oil Blends And Structured Lipids And Their Effect On Wound Healingpt_BR
dc.contributor.authorRodrigues Ractpt_BR
dc.contributor.authorJuliana Neves; Schaefer De Martini Soarespt_BR
dc.contributor.authorFabiana Andreia; Rodriguespt_BR
dc.contributor.authorHosana Gomes; Bortolonpt_BR
dc.contributor.authorJose Ricardo; Muratapt_BR
dc.contributor.authorGilson Masahiro; Almeida Goncalvespt_BR
dc.contributor.authorMaria Ines; Hatanakapt_BR
dc.contributor.authorElaine; Cuript_BR
dc.contributor.authorRui; Gioiellipt_BR
dc.contributor.authorLuiz Antoniopt_BR
unicamp.author.emailjulianaract@usp.brpt_BR
unicamp.author[Rodrigues, Hosana Gomes] Univ Estadual Campinas, Fac Sci Appl, Lab Biotechnol, Campinas, SP, Brazilpt_BR
unicamp.author.external[Rodrigues Ract, Juliana Nevespt
unicamp.author.externalSchaefer De Martini Soares, Fabiana Andreiapt
unicamp.author.externalGioielli, Luiz Antonio] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Sao Paulo, SP, Brazilpt
unicamp.author.external[Bortolon, Jose Ricardopt
unicamp.author.externalHatanaka, Elaine] Univ Cruzeiro Sul, Inst Phys Activ Sci & Sports, Sao Paulo, SP, Brazilpt
unicamp.author.external[Murata, Gilson Masahiropt
unicamp.author.externalCuri, Rui] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP, Brazilpt
unicamp.author.external[Almeida Goncalves, Maria Ines] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, SP, Brazilpt
dc.subjectFatty-acidspt_BR
dc.subjectLinoleic Acidspt_BR
dc.subjectCoconut Oilpt_BR
dc.subjectSesame Oilpt_BR
dc.subjectTriacylglycerolspt_BR
dc.subjectRatspt_BR
dc.subjectInteresterificationpt_BR
dc.subjectAcidolysispt_BR
dc.subjectStearinpt_BR
dc.description.abstractTwo oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group), Blends (TBL), and Structured Lipids (TSL). The control group (TPS) received physiological saline solution for 15 days. In TBL, BL1 was administered during the inflammation phase (days 0-3) and BL2 in the tissue formation and remodeling phase (days 4-15). In TSL, Structured Lipid 1 (SL1) and Structured Lipid 2 (SL2) were used instead of BL1 and BL2, respectively. The aim of this study was to compare wound closure evolution among rats treated with the blends or structured lipids versus control rats treated with physiological saline. The wound healing process was evaluated by measuring the wound areas along the treatments and the concentrations of cytokines. An increase in the areas of wounds treated with the blends and structured lipids in the inflammatory phase was observed, followed by a steeper closure curve compared to wounds treated with physiological saline. The changes observed during the inflammatory phase suggest a potential therapeutic application in cutaneous wound healing which should be further investigated.en
dc.relation.ispartofBRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCESpt_BR
dc.publisher.countrySAO PAULOpt_BR
dc.publisherUNIV SAO PAULO, CONJUNTO QUIMICASpt_BR
dc.date.issued2015-APR-JUNpt_BR
dc.identifier.citationProduction Of Vegetable Oil Blends And Structured Lipids And Their Effect On Wound Healing. Univ Sao Paulo, Conjunto Quimicas, v. 51, p. 415-427 APR-JUN-2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume51pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage415pt_BR
dc.description.lastpage427pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1984-8250pt_BR
dc.identifier.wosidWOS:000359468400019pt_BR
dc.identifier.doi10.1590/S1984-82502015000200019pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200415&lng=en&nrm=iso&tlng=enpt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2016-06-07T13:34:02Z-
dc.date.accessioned2016-06-07T13:34:02Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:34:02Z (GMT). No. of bitstreams: 1 wos_000359468400019.pdf: 401889 bytes, checksum: b4469fedb9ffc48a5666b7113a29a8d5 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243831-
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