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Type: Artigo de periódico
Title: Uncommon Trimethoxylated Flavonol Obtained From Rubus Rosaefolius Leaves And Its Antiproliferative Activity
Author: Petreanu
Marcel; Ferreira
Emili Kamila; Sagaz
Ana Paula M.; Vendramini-Costa
Debora B.; Ruiz
Ana Lucia T. G.; De Carvalho
Joao Ernesto; Campos
Adriana; Cechinel Filho
Valdir; Delle Monache
Franco; Niero
Abstract: This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R. rosaefolius leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H-1 and C-13 and identified as 5,7-dihydroxy-6,8,4'-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (2), and tormentic acid (3). Both hexane and dichloromethane fractions showed selectivity formultidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 mu g/ml, respectively. Compound 1 also showed selective activity against the same cell line (18.8 mu g/ml); however, it was especially effective against glioma cells (2.8 mu g/ml), suggesting that this compound may be involved with the in vitro antiproliferative action.
Subject: Anticancer Drug Screen
Induced Dna-damage
Human Cancer-cells
Potential Chemoprevention
Rosaceae Extract
Country: NEW YORK
Rights: aberto
Identifier DOI: 10.1155/2015/341216
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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