Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243527
Type: Artigo de periódico
Title: Serum Interleukin-17 Levels Are Associated With Nephritis In Childhood-onset Systemic Lupus Erythematosus
Author: Pelicari
Karina de Oliveira; Postal
Mariana; Sinicato
Nailu Angelica; Peres
Fernando Augusto; Fernandes
Paula Teixeira; Marini
Roberto; Lavras Costallat
Lilian Tereza; Appenzeller
Simone
Abstract: OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age-and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p = 0.009). We observed an association between serum IL-17 levels and active nephritis (p = 0.01) and migraines (p = 0.03). Serum IL-17 levels were not associated with disease activity (p = 0.32), cumulative damage (p = 0.34), or medication use (p = 0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus.
Subject: Disease-activity
Alpha Activity
Damage Index
T-cells
Il-17
Il-23
Cytokines
Expression
Depression
Inventory
Country: SAO PAULO
Editor: HOSPITAL CLINICAS, UNIV SAO PAULO
Citation: Serum Interleukin-17 Levels Are Associated With Nephritis In Childhood-onset Systemic Lupus Erythematosus. Hospital Clinicas, Univ Sao Paulo, v. 70, p. 313-317 2015.
Rights: fechado
Identifier DOI: 10.6061/clinics/2015(05)01
Address: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-59322015000500313&lng=en&nrm=iso&tlng=en
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
wos_000355800500001.pdf240.92 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.