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Type: Artigo de periódico
Title: Interlocked Systems In Nanomedicine
Author: Ornelas-Megiatto
Catia; Becher
Tiago B.; Megiatto
Jackson D.
Abstract: The concept of Nanomedicine emerged along with the new millennium, and it is expected to provide solutions to some of modern medicine's unsolved problems. Nanomedicine offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, tissue regeneration, and theranostics. To explore all these applications, a wide variety of nanomaterials have been developed which include liposomes, dendrimers, nanohydrogels and polymeric, metallic and inorganic nanoparticles. Recently, interlocked systems, namely rotaxanes and catenanes, have been incorporated into some of these chemical platforms in an attempt to improve their performance. This review focus on the nanomedicine applications of nanomaterials containing interlocked structures. The introduction gives an overview on the significance of interdisciplinary science in the progress of the nanomedicine field, and it explains the evolution of interlocked molecules until their application in nanomedicine. The following sections are organized by the type of interlocked structure, and it comprises details of the in vitro and/or in vivo experiments involving each material: rotaxanes as imaging agents, rotaxanes as cytotoxic agents, rotaxanes as peptide transporters, mechanized silica nanoparticles as stimuli responsive drug delivery systems, and polyrotaxanes as drug and gene delivery systems.
Subject: Cyclodextrin-based Polyrotaxanes
Sustained-release System
Controlled Drug-release
Mesoporous Silica Nanoparticles
Gene Delivery
Biomedical Applications
Molecular Machines
Supramolecular Hydrogels
Country: SHARJAH
Citation: Interlocked Systems In Nanomedicine. Bentham Science Publ Ltd, v. 15, p. 1236-1256 2015.
Rights: fechado
Identifier DOI: 10.2174/1568026615666150330111614
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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