Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243462
Type: Artigo de periódico
Title: Effects Of Hyperbaric Oxygen On Pseudomonas Aeruginosa Susceptibility To Imipenem And Macrophages
Author: Lima
Flavia Luna; Joazeiro
Paulo Pinto; Lancellotti
Marcelo; de Hollanda
Luciana Maria; Lima
Bruna de Araujo; Linares
Edlaine; Augusto
Ohara; Brocchi
Marcelo; Giorgio
Selma
Abstract: Background: The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). Materials & methods: The effects of HBO (100% O-2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six isolates of P. aeruginosa and bacterial ultrastructure were investigated. Infected macrophages were exposed to HBO (100% O-2, 3 ATA, 90 min) and the production of reactive oxygen species monitored. Results: HBO enhanced the effects of imipenen. HBO increased superoxide anion production by macrophages and likely kills bacteria by oxidative mechanisms. Conclusion: HBO in combination with imipenem
Subject: Antibiotics
Inhibition
Mechanisms
Hyperoxia
Therapy
Growth
Cells
Enhancement
Superoxide
Infections
Country: LONDON
Editor: FUTURE MEDICINE LTD
Rights: fechado
Identifier DOI: 10.2217/FMB.14.111
Address: http://www.futuremedicine.com/doi/abs/10.2217/fmb.14.111?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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