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Type: Artigo de periódico
Title: Association Of Loc387715/arms2 (rs10490924) Gene Polymorphism With Age-related Macular Degeneration In The Brazilian Population
Author: Hirata
Fabio Endo; Cabral de Vasconcellos
Jose Paulo; Medina
Flavio MacCord; Hyun Rim
Priscila Hae; Medeiros Fulco
Enzo Augusto; de Melo
Monica Barbosa
Abstract: Background: An association between LOC387715/ARMS2 (rs10490924) gene polymorphism and AMD has been reported. The aim of this study was to evaluate whether this polymorphism is associated with AMD in a Brazilian cohort. Materials and Methods: In total, 126 unrelated AMD patients (mean age 74.17 +/- 7.64) were compared with 86 healthy controls (mean age 71.82 +/- 7.12). Study subjects were classified according to the International ARM Epidemiological Study Group definition for early and late-stage AMD. LOC387715/ARMS2 rs10490924 polymorphism was evaluated through polymerase chain reaction and direct sequencing. Results: The T allele frequency was significantly higher in AMD patients than in controls (39.6% compared to 20.3%). The odds ratio (OR) for AMD was 2.05 (95% CI 1.13-3.71) for heterozygotes (TG) and 8.32 (95% CI 2.30-45.99) for homozygotes (TT). Conclusions: These results suggest that there is a contribution of the rs10490924 SNP of the LOC387715/ARMS2 gene to AMD susceptibility in this sample of the Brazilian population.
Subject: Complement Factor-h
Chromosome 10q26
Rights: embargo
Identifier DOI: 10.3109/13816810.2013.867449
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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