Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243222
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleVirulence And Pathogenicity Of Candida Albicans Is Enhanced In Biofilms Containing Oral Bacteriapt_BR
dc.contributor.authorCavalcantipt_BR
dc.contributor.authorYuri Wanderley; Morsept_BR
dc.contributor.authorDaniel James; da Silvapt_BR
dc.contributor.authorWander Jose; Del-Bel-Curypt_BR
dc.contributor.authorAltair Antoninha; Weipt_BR
dc.contributor.authorXiaoqing; Wilsonpt_BR
dc.contributor.authorMelanie; Milwardpt_BR
dc.contributor.authorPaul; Lewispt_BR
dc.contributor.authorMichael; Bradshawpt_BR
dc.contributor.authorDavid; Williamspt_BR
dc.contributor.authorDavid Wynnept_BR
unicamp.author.emailCavalcantiY@cardiff.ac.ukpt_BR
unicamp.authorDel-Bel-Cury, Altair Antoninha] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba, SP, Brazilpt_BR
unicamp.author.external[Cavalcanti, Yuri Wanderleypt
unicamp.author.externalda Silva, Wander Josept
unicamp.author.external[Cavalcanti, Yuri Wanderleypt
unicamp.author.externalMorse, Daniel Jamespt
unicamp.author.externalWei, Xiaoqingpt
unicamp.author.externalWilson, Melaniept
unicamp.author.externalMilward, Paulpt
unicamp.author.externalLewis, Michaelpt
unicamp.author.externalBradshaw, Davidpt
unicamp.author.externalWilliams, David Wynne] Cardiff Univ, Sch Dent, Cardiff CF10 3AX, S Glam, Walespt
dc.subjectPseudomonas-aeruginosapt_BR
dc.subjectInflammatory Responsept_BR
dc.subjectEpithelial-cellspt_BR
dc.subjectGene-expressionpt_BR
dc.subjectIn-situpt_BR
dc.subjectModelpt_BR
dc.subjectIdentificationpt_BR
dc.subjectGlabratapt_BR
dc.subjectHyphalpt_BR
dc.subjectCoinfectionpt_BR
dc.description.abstractThis study examined the influence of bacteria on the virulence and pathogenicity of candidal biofilms. Mature biofilms (Candida albicans-only, bacteria-only, C. albicans with bacteria) were generated on acrylic and either analysed directly, or used to infect a reconstituted human oral epithelium (RHOE). Analyses included Candida hyphae enumeration and assessment of Candida virulence gene expression. Lactate dehydrogenase (LDH) activity and Candida tissue invasion following biofilm infection of the RHOE were also measured. Candida hyphae were more prevalent (p < 0.05) in acrylic biofilms also containing bacteria, with genes encoding secreted aspartyl-proteinases (SAP4/SAP6) and hyphal-wall protein (HWP1) up-regulated (p < 0.05). Candida adhesin genes (ALS3/EPA1), SAP6 and HWP1 were up-regulated in mixed-species biofilm infections of RHOE. Multi-species infections exhibited higher hyphal proportions (p < 0.05), up-regulation of IL-18, higher LDH activity and tissue invasion. As the presence of bacteria in acrylic biofilms promoted Candida virulence, consideration should be given to the bacterial component when managing denture biofilm associated candidoses.en
dc.relation.ispartofBIOFOULINGpt_BR
dc.publisher.countryABINGDONpt_BR
dc.publisherTAYLOR & FRANCIS LTDpt_BR
dc.date.issued2015pt_BR
dc.identifier.citationVirulence And Pathogenicity Of Candida Albicans Is Enhanced In Biofilms Containing Oral Bacteria. Taylor & Francis Ltd, v. 31, p. 27-38 2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume31pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage27pt_BR
dc.description.lastpage38pt_BR
dc.rightsembargopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0892-7014pt_BR
dc.identifier.wosidWOS:000348531500004pt_BR
dc.identifier.doi10.1080/08927014.2014.996143pt_BR
dc.identifier.urlhttp://www.tandfonline.com/doi/full/10.1080/08927014.2014.996143pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipGlaxoSmithKline under EPSRC-CASE awardpt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberCAPES [007355/2013-00]pt
dc.description.sponsordocumentnumberFAPESP [2012/07436-6]pt
dc.date.available2016-06-07T13:22:18Z-
dc.date.accessioned2016-06-07T13:22:18Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:22:18Z (GMT). No. of bitstreams: 1 wos_000348531500004.pdf: 1332292 bytes, checksum: 5948237b0f62ae04a42017b5f845226a (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243222-
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