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Type: Artigo de periódico
Title: Nature-inspired Enzymatic Cascades To Build Valuable Compounds
Author: Sigrist
Renata; da Costa
Bruna Zucoloto; Marsaioli
Anita Jocelyne; de Oliveira
Luciana Gonzaga
Abstract: Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases. (C) 2015 Elsevier Inc. All rights reserved.
Subject: Biosynthetic Gene-cluster
Assembly-line Enzymology
Squalene-hopene Cyclases
Red Tide Dinoflagellate
Stereoselective Monoamination
2,6-disubstituted Piperidines
Oxidative Cyclization
Country: OXFORD
Citation: Nature-inspired Enzymatic Cascades To Build Valuable Compounds. Pergamon-elsevier Science Ltd, v. 33, p. 394-411 SEP-OCT-2015.
Rights: embargo
Identifier DOI: 10.1016/j.biotechadv.2015.03.010
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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