Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242929
Type: Artigo de periódico
Title: Association Between Cationic Liposomes And Low Molecular Weight Hyaluronic Acid
Author: Gasperini
Antonio A. M.; Puentes-Martinez
Ximena E.; Balbino
Tiago Albertini; Rigoletto
Thais de Paula; Cavalcanti Correa
Gabriela de Sa; Cassago
Alexandre; Portugal
Rodrigo Villares; de La Torre
Lucimara Gaziola; Cavalcanti
Leide P.
Abstract: This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The cationic liposome/HA complexes were evaluated to determine their mesoscopic structure, average size, zeta potential, and morphology as a function of the amount of HA in the system. Small angle X-ray scattering results revealed that neighboring cationic liposomes either stick together after a partial coating of low concentration HA or disperse completely in excess of HA, but they never assemble as multilamellar vesicles. Cryo-transmission electron microscopy images confirm the existence of unilamellar vesicles and large aggregates of unilamellar vesicles for HA fractions up to 80% (w/w). High concentrations of HA (> 20% w/w) proved to be efficient for coating extruded liposomes, leading to particle complexes with sizes in the nanoscale range and a negative zeta potential.
Subject: Gene-therapy
Delivery
Cd44
Complexes
Prospects
Progress
Cancer
Cells
Epc/dotap/dope
Nanoparticles
Country: WASHINGTON
Editor: AMER CHEMICAL SOC
Citation: Association Between Cationic Liposomes And Low Molecular Weight Hyaluronic Acid. Amer Chemical Soc, v. 31, p. 3308-3317 Mar-2015.
Rights: fechado
Identifier DOI: 10.1021/la5045865
Address: http://pubs.acs.org/doi/abs/10.1021/la5045865
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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