Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242828
Type: Artigo de periódico
Title: Permeation Profiles Of Resveratrol Cream Delivered Through Porcine Vaginal Mucosa: Evaluation Of Different Hplc Stationary Phases
Author: Polonini
Hudson Caetano; Soldati
Pedro Paulo; de Almeida
Priscila Aparecida; Azevedo da Silva
Carla Grazieli; Collins
Carol Hollingworth; Leal de Oliveira
Marcone Augusto; Ferreira
Anderson de Oliveira; Barbosa Raposo
Nadia Rezende; Fernandes Brandao
Marcos Antonio
Abstract: Trans-resveratrol affects biological systems in a multitude of ways, but its oral bioavailability is remarkably poor due to in vivo metabolization. This drawback has fomented the development of new strategies for systemic delivery, such as transmucosal delivery via the vaginal route, which is our main focus here. In this sense, our pioneering study purposed to evaluate the trans-resveratrol permeation efficacy through this route. For that, we used a previously validated method and tested it with three different stationary phases: a commercial C18 column and two laboratory-made chromatographic columns containing poly(methyloctadecylsiloxane) (PMODS) thermally immobilized onto zirconized silica (Zr-PMODS) or titanized silica (Ti-PMODS). The permeation experiments showed that resveratrol, in the formulation used, was not successfully delivered to the bloodstream - it was actually retained within the vaginal mucosa, which suggests a local use rather a systemic one. (C) 2015 Elsevier B.V. All rights reserved.
Subject: Performance Liquid-chromatography
Drug-release
In-vitro
Silica
Bioavailability
Country: AMSTERDAM
Editor: ELSEVIER SCIENCE BV
Citation: Permeation Profiles Of Resveratrol Cream Delivered Through Porcine Vaginal Mucosa: Evaluation Of Different Hplc Stationary Phases. Elsevier Science Bv, v. 1002, p. 8-12 OCT-2015.
Rights: embargo
Identifier DOI: 10.1016/j.jchromb.2015.07.057
Address: http://www.sciencedirect.com/science/article/pii/S1570023215301240
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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