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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNeutralization Of The Neuromuscular Inhibition Of Venom And Taipoxin From The Taipan (oxyuranus Scutellatus) By F(ab ') 2 And Whole Igg Antivenomspt_BR
dc.contributor.authorHerrerapt_BR
dc.contributor.authorMaria; de O Collacopt_BR
dc.contributor.authorRita de Cassia; Villaltapt_BR
dc.contributor.authorMauren; Segurapt_BR
dc.contributor.authorAlvaro; Vargaspt_BR
dc.contributor.authorMariangela; Wrightpt_BR
dc.contributor.authorChristine E.; Paivapt_BR
dc.contributor.authorOwen K.; Matainahopt_BR
dc.contributor.authorTeatulohi; Jensenpt_BR
dc.contributor.authorSimon D.; Leonpt_BR
dc.contributor.authorGuillermo; Williamspt_BR
dc.contributor.authorDavid J.; Rodrigues-Simionipt_BR
dc.contributor.authorLea; Maria Gutierrezpt_BR
dc.contributor.authorJosept_BR
unicamp.author.emailjose.gutierrez@ucr.ac.crpt_BR
unicamp.authorRodrigues-Simioni, Lea] State Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazilpt_BR
unicamp.author.external[Herrera, Mariapt
unicamp.author.externalVillalta, Maurenpt
unicamp.author.externalSegura, Alvaropt
unicamp.author.externalVargas, Mariangelapt
unicamp.author.externalLeon, Guillermopt
unicamp.author.externalMaria Gutierrez, Jose] Univ Costa Rica, Fac Microbiol, Inst Clodomiro Picado, San Jose, Costa Ricapt
unicamp.author.external[de O Collaco, Rita de Cassiapt
unicamp.author.external[Wright, Christine E.pt
unicamp.author.externalJensen, Simon D.pt
unicamp.author.externalWilliams, David J.] Univ Melbourne, Dept Pharmacol & Therapeut, Australian Venom Res Unit, Parkville, Vic 3052, Australiapt
unicamp.author.external[Paiva, Owen K.pt
unicamp.author.externalMatainaho, Teatulohipt
unicamp.author.externalJensen, Simon D.pt
unicamp.author.externalWilliams, David J.] Univ Papua New Guinea, Sch Med & Hlth Sci, Charles Campbell Toxinol Ctr, Port Moresby, Papua N Guineapt
dc.subjectPapua-new-guineapt_BR
dc.subjectPresynaptic Neurotoxinpt_BR
dc.subjectSnake-venompt_BR
dc.subjectElectrocardiographic Abnormalitiespt_BR
dc.subjectAcetylcholine-receptorpt_BR
dc.subjectPhospholipases A(2)pt_BR
dc.subjectBeta-bungarotoxinpt_BR
dc.subjectCannipt_BR
dc.subjectBindingpt_BR
dc.subjectMicrolepidotuspt_BR
dc.description.abstractThe neuromuscular junction activity of Oxyuranus scutellatus venom and its presynaptic neurotoxin, taipoxin, and their neutralization by two antivenoms were examined in mouse phrenic nerve-diaphragm preparations. The action of taipoxin was also studied at 21 degrees C. The efficacy of the antivenoms was also assessed in an in vivo mouse model. Both antivenoms were effective in neutralizing the neuromuscular blocking activity in preincubation-type experiments. In experiments involving independent addition of venom and antivenoms, neutralization depended on the time interval between venom addition and antivenom application. When taipoxin was incubated for 5, 10 or 20 min at 21 degrees C, and antivenom added and temperature increased to 37 degrees C, neutralization was achieved only when the toxin was incubated for 5 or 10 min. The neutralization by the two antivenoms in an in vivo model showed that both whole IgG and F(ab')(2) antivenoms were effective in neutralizing lethality. Our findings highlight the very rapid action of taipan venom at the nerve terminal, and the poor capacity of antivenoms to revert neurotoxicity as the time interval between venom or taipoxin application and antivenom addition increased. Additionally the disparity between molecular masses of the active substances of the two antivenoms did not result in differences in neutralization. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en
dc.relation.ispartofTOXICOLOGY LETTERSpt_BR
dc.publisher.countryCLAREpt_BR
dc.publisherELSEVIER IRELAND LTDpt_BR
dc.date.issued2016-Janpt_BR
dc.identifier.citationNeutralization Of The Neuromuscular Inhibition Of Venom And Taipoxin From The Taipan (oxyuranus Scutellatus) By F(ab ') 2 And Whole Igg Antivenoms. Elsevier Ireland Ltd, v. 241, p. 175-183 Jan-2016.pt_BR
dc.language.isoenpt_BR
dc.description.volume241pt_BR
dc.description.firstpage175pt_BR
dc.description.lastpage183pt_BR
dc.rightsembargopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0378-4274pt_BR
dc.identifier.wosidWOS:000367653700019pt_BR
dc.identifier.doi10.1016/j.toxlet.2015.11.020pt_BR
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378427415301168pt_BR
dc.description.sponsorshipVicerrectoria de Investigacion, University of Costa Ricapt_BR
dc.description.sponsorshipAustralian National Health and Medical Research Council [1033977]pt_BR
dc.description.sponsorshipSutherland Trustpt_BR
dc.date.available2016-06-07T13:19:58Z-
dc.date.accessioned2016-06-07T13:19:58Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:19:58Z (GMT). No. of bitstreams: 1 wos_000367653700019.pdf: 881263 bytes, checksum: 8f494609e3927749226ce00c3d871d47 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242806-
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