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Type: Artigo de periódico
Title: Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors
Author: Serra, Katia Piton
Sarian, Luis Otavio
Rodrigues-Peres, Raquel Mary
Vassallo, Jose
Soares, Fernando Augusto
Pinto, Glauce Aparecida
da Cunha, Isabela Werneck
Shinzato, Julia Yoriko
Derchain, Sophie F. M.
Abstract: The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components. (C) 2011 Elsevier GmbH. All rights reserved.
Subject: Breast cancer
Hormonal receptor
Editor: Elsevier
Citation: Acta Histochemica. Elsevier, v.114, n.3, p.226-231, 2012
Rights: fechado
Identifier DOI: 10.1016/j.acthis.2011.05.001
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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