Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242779
Type: Artigo de periódico
Title: Green Propolis Modulates Gut Microbiota, Reduces Endotoxemia And Expression Of Tlr4 Pathway In Mice Fed A High-fat Diet
Author: Roquetto
Aline Rissetti; Santana Monteiro
Naice Eleidiane; Moura
Carolina Soares; Toreti
Viviane Cristina; de Pace
Fernanda; dos Santos
Andrey; Park
Yong Kun; Amaya-Farfan
Jaime
Abstract: Due to the various beneficial effects attributed to propolis, which include anti-inflammatory and anti-bacterial infection properties, the objective of the study was to evaluate the effect of propolis supplementation on the composition of the intestinal microbiota and its anti-inflammatory action. Forty male C57BL/6 mice were fed either a standard diet (control), a high-fat (HF) diet, or a high-fat diet supplemented with 0.2% crude propolis (HFP) for 2 or 5 weeks prior to sacrifice. Blood samples were collected for the determination of lipopolysaccharide (LPS) and classical biochemical parameters. Expression of the TLR4 pathway in muscle, and DNA sequencing for the 16S rRNA of the gut microbiota were performed. The HF diet increased the proportion of the phylum Firmicutes and inflammatory biomarkers, while supplementation with propolis for five weeks rendered the microbiota profile nearly normal. Consistently with the above, the supplementation reduced levels of circulating LPS and down-regulated the TLR4 pathway and inflammatory cytokine expressions in muscle. Moreover, propolis improved such biochemical parameters as serum triacylglycerols and glucose levels. The data suggest that propolis supplementation reduces inflammatory response and endotoxemia by preventing dysbiosis in mice challenged with a high-fat diet. (C) 2015 Elsevier Ltd. All rights reserved.
Subject: Metabolic Endotoxemia
Brazilian Propolis
Botanical Origin
Lipid-metabolism
Induced Obesity
Energy
Rats
Recognition
Muscle
Honey
Country: AMSTERDAM
Editor: ELSEVIER SCIENCE BV
Rights: embargo
Identifier DOI: 10.1016/j.foodres.2015.07.026
Address: http://www.sciencedirect.com/science/article/pii/S0963996915301149
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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