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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampVieira, Briana Rachid Diaspt_BR
dc.contributor.authorunicampLee, Simone Van de Sandept_BR
dc.contributor.authorunicampGeloneze, Sylka D'Oliveira Rodovalhopt_BR
dc.contributor.authorunicampBeltramini, Guilherme Côcopt_BR
dc.contributor.authorunicampMorari, Joseanept_BR
dc.contributor.authorunicampAmorim, Bárbara Juarezpt_BR
dc.contributor.authorunicampPedro, Tatianept_BR
dc.contributor.authorunicampGarcia, Albina de Fátima Silva Ramalhopt_BR
dc.contributor.authorunicampBombassaro, Brunapt_BR
dc.contributor.authorunicampTincani, Alfio Josépt_BR
dc.contributor.authorunicampChaim, Elinton Adamipt_BR
dc.contributor.authorunicampPareja, José Carlospt_BR
dc.contributor.authorunicampGeloneze Neto, Brunopt_BR
dc.contributor.authorunicampRamos, Celso Daríopt_BR
dc.contributor.authorunicampCendes, Fernandopt_BR
dc.contributor.authorunicampSaad, Mario José Abdallapt_BR
dc.contributor.authorunicampVelloso, Licio Augustopt_BR
dc.typeArtigopt_BR
dc.titleDistinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesitypt_BR
dc.contributor.authorRachid, B.pt_BR
dc.contributor.authorvan de Sande-Lee, S.pt_BR
dc.contributor.authorRodovalho, S.pt_BR
dc.contributor.authorFolli, F.pt_BR
dc.contributor.authorBeltramini, G. C.pt_BR
dc.contributor.authorMorari, J.pt_BR
dc.contributor.authorAmorim, B. J.pt_BR
dc.contributor.authorPedro, T.pt_BR
dc.contributor.authorRamalho, A. F.pt_BR
dc.contributor.authorBombassaro, B.pt_BR
dc.contributor.authorTincani, A. J.pt_BR
dc.contributor.authorChaim, E.pt_BR
dc.contributor.authorPareja, J. C.pt_BR
dc.contributor.authorGeloneze, B.pt_BR
dc.contributor.authorRamos, C. D.pt_BR
dc.contributor.authorCendes, F.pt_BR
dc.contributor.authorSaad, M. J. A.pt_BR
dc.contributor.authorVelloso, L. A.pt_BR
dc.subjectTecido adiposo marrompt_BR
dc.subjectObesidadept_BR
dc.subjectMetabolismopt_BR
dc.subject.otherlanguageAdipose tissue, brownpt_BR
dc.subject.otherlanguageObesitypt_BR
dc.subject.otherlanguageMetabolismpt_BR
dc.description.abstractBACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.en
dc.description.abstractThe identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonancept
dc.description.abstractBACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to coldpt_BR
dc.description.abstracthowever, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.pt_BR
dc.relation.ispartofInternational journal of obesitypt_BR
dc.relation.ispartofabbreviationInt. j. obes.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherNature Publishing Grouppt_BR
dc.date.issued2015pt_BR
dc.date.monthofcirculationOct.pt_BR
dc.identifier.citationDistinct Regulation Of Hypothalamic And Brown/beige Adipose Tissue Activities In Human Obesity. Nature Publishing Group, v. 39, p. 1515-1522 OCT-2015.pt_BR
dc.language.isoengpt_BR
dc.description.volume39pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage1515pt_BR
dc.description.lastpage1522pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0307-0565pt_BR
dc.identifier.eissn1476-5497pt_BR
dc.identifier.doi10.1038/ijo.2015.94pt_BR
dc.identifier.urlhttps://www.nature.com/articles/ijo201594pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2016-06-07T13:19:49Z-
dc.date.accessioned2016-06-07T13:19:49Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:19:49Z (GMT). No. of bitstreams: 1 wos_000364960700016.pdf: 2558068 bytes, checksum: dc6f873d7f6170ee6908bf18059940a3 (MD5) Previous issue date: 2015 Bitstreams deleted on 2020-05-18T20:41:35Z: wos_000364960700016.pdf,. Added 1 bitstream(s) on 2020-05-19T14:31:38Z : No. of bitstreams: 1 000364960700016.pdf: 2632109 bytes, checksum: 73a38c1f054f0f0a5a3ee6529f44c457 (MD5) Bitstreams deleted on 2020-09-02T13:40:03Z: 000364960700016.pdf,. Added 1 bitstream(s) on 2020-09-02T13:44:04Z : No. of bitstreams: 1 000364960700016.pdf: 3137412 bytes, checksum: b9295b4bb0d9e73ac6a98c6016dc429f (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242772-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Raios Cósmicos e Cronologiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Radiologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Radiologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000364960700016pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5592-1603pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-8911-3604pt_BR
dc.creator.orcid0000-0002-0728-4283pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-6193-2686pt_BR
dc.creator.orcid0000-0003-4627-0631pt_BR
dc.creator.orcid0000-0001-8993-7147pt_BR
dc.creator.orcid0000-0002-0557-4578pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-9336-9568pt_BR
dc.creator.orcid0000-0003-4544-6105pt_BR
dc.creator.orcid0000-0002-4806-7218pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteWe thank E. Roman and G. Ferraz from the University of Campinas for technical assistance. Support for the study was provided by the Fundação de Amparo a Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico and grants from the Trust in Science Initiative from Glaxo-Smithkline, UK. The Laboratories of Cell Signaling and Experimental Endocrinology belong to the Obesity and Comorbidities Research Center and the National Institute of Science and Technology–Diabetes and Obesity.pt_BR
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