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Type: Artigo de periódico
Title: Distinct Regulation Of Hypothalamic And Brown/beige Adipose Tissue Activities In Human Obesity
Author: Rachid
B.; van de Sande-Lee
S.; Rodovalho
S.; Folli
F.; Beltramini
G. C.; Morari
J.; Amorim
B. J.; Pedro
T.; Ramalho
A. F.; Bombassaro
B.; Tincani
A. J.; Chaim
E.; Pareja
J. C.; Geloneze
B.; Ramos
C. D.; Cendes
F.; Saad
M. J. A.; Velloso
L. A.
Abstract: BACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.
Subject: Diet-induced Obesity
Acute Cold-exposure
Synaptic Plasticity
Adult Humans
Brown Fat
Country: LONDON
Citation: Distinct Regulation Of Hypothalamic And Brown/beige Adipose Tissue Activities In Human Obesity. Nature Publishing Group, v. 39, p. 1515-1522 OCT-2015.
Rights: fechado
Identifier DOI: 10.1038/ijo.2015.94
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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