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Type: Artigo de periódico
Title: Propagation Of Pathology Through Brain Networks In Neurodegenerative Diseases: From Molecules To Clinical Phenotypes
Author: Agosta
Federica; Weiler
Marina; Filippi
Abstract: The cellular mechanisms underlying the stereotypical progression of pathology in neurode-generative diseases are incompletely understood, but increasing evidence indicates that misfolded protein aggregates can spread by a self-perpetuating neuron-to-neuron transmission. Novel neuroimaging techniques can help elucidating how these disorders spread across brain networks. Recent knowledge from structural and functional connectivity studies suggests that the relation between neurodegenerative diseases and distinct brain networks is likely to be a strict consequence of diffuse network dynamics. Diffusion tensor magnetic resonance imaging also showed that measurement of white matter tract involvement can be a valid surrogate to assess the in vivo spreading of pathological proteins in these conditions. This review will introduce briefly the main molecular and pathological substrates of the most frequent neurodegenerative diseases and provide a comprehensive overview of neuroimaging findings that support the "network-based neurodegeneration" hypothesis in these disorders. Characterizing network breakdown in neurodegenerative diseases will help anticipate and perhaps prevent the devastating impact of these conditions.
Subject: Amyotrophic-lateral-sclerosis
Mild Cognitive Impairment
Frontotemporal Lobar Degeneration
Default-mode Network
Alzheimers Association Workgroups
Intrinsic Connectivity Networks
State Functional Connectivity
Sporadic Parkinsons-disease
Posterior Cortical Atrophy
White-matter Changes
Country: HOBOKEN
Rights: fechado
Identifier DOI: 10.1111/cns.12410
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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