Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242496
Type: Artigo de periódico
Title: Sequential Morita-baylis-hillman/achmatowicz Reactions: An Expeditious Access To Pyran-3(6h)-ones With A Unique Substitution Pattern
Author: Guidotti
Bruno B.; Coelho
Fernando
Abstract: We herein disclosed a novel approach to synthesize densely functionalized 6-hydroxy-2H-pyran-3(6H)-ones with moderate to good diastereoselectivity. The method is based on a two step sequence using Morita-Baylis-Hillman adducts as substrates for the Achmatowicz rearrangement, allowing the preparation of highly substituted pyran-3-ones with overall yields ranging from 17% to 80% and a unique substitution pattern. (C) 2015 Elsevier Ltd. All rights reserved.
Subject: Stereoselective Total-synthesis
Novo Asymmetric-synthesis
Hillman Reaction
Enantioselective Synthesis
Achmatowicz Reaction
(+)-phomopsolide B
Furan-derivatives
Organic-synthesis
Cross-metathesis
General-approach
Country: OXFORD
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Rights: embargo
Identifier DOI: 10.1016/j.tetlet.2015.09.120
Address: http://www.sciencedirect.com/science/article/pii/S0040403915301635
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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