Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242412
Type: Artigo de periódico
Title: Use Of Cystatin C And Serum Creatinine For The Diagnosis Of Contrast-induced Nephropathy In Patients Undergoing Contrast-enhanced Computed Tomography At An Oncology Centre
Author: Fortalesa Melo
Joao Italo; Chojniak
Rubens; Costa Silva
Debora Helena; Oliveira Junior
Jose Carlos; Vieira Bitencourt
Almir Galvao; Silva
Diego Holanda; Guimaraes
Marcos Duarte; Souza Silva
Hernandes Cerqueira; Teixeira Dias
Denis Guilherme; Rodrigues
Winglison Carli; Brancucci
Ellen Luzia; Soares Cruz
Barbara Martins; Schiavon
Beatriz Nunes; Passos Argenton
Juliana Luz; Camporini
Margareth Arrivabene; Zocchio
Adriana
Abstract: Objective Our aim was to assess renal function using as laboratory measurements serum creatinine and cystatin C concentrations before and after administration of low-osmolarity (nonionic) iodinated contrast medium in patients with cancer undergoing computed tomography (CT). Methods This prospective study included 400 oncologic outpatients. Serum creatinine and cystatin C concentrations were measured before and 72 h after contrast administration. Glomerular filtration rates (GFRs) were estimated using serum creatinine-based [Modification of Diet in Renal Disease (MDRD) and Cockroft-Gault and cystatin C based (Larsson) equations. Exploratory data analysis was performed. The nonparametric Wilcoxon test was used to compare pre and post contrast of test results and estimated clearance. The confidence interval used in the analysis was 95%. Results Compared with the pre-contrast values, the mean serum creatinine concentration was significantly higher and average GFRs estimated using MDRD and Cockcroft-Gault equations were significantly lower after the administration of contrast (p < 0.001). It was also observed a significant increase after contrast in the concentration of Cystatin C (p = 0.015). In addition, a decrease in GFR estimated using the average Larsson (p = 0.021) was observed between time points. However, none of the patients presented clinically significant nephropathy. Conclusions Assessment using serum creatinine and cystatin C concentrations showed changes in renal function among patients with cancer undergoing contrast-enhanced CT examination in this study. No significant renal damage related to the use of low-osmolarity iodinated contrast medium of the type and dosage employed in this study was observed. This contrast medium is thus safe for use in patients with cancer.
Subject: Glomerular-filtration-rate
Acute Kidney Injury
Acute-renal-failure
Insufficiency
Media
Nephrotoxicity
Disease
Marker
Cancer
Metaanalysis
Country: SAN FRANCISCO
Editor: PUBLIC LIBRARY SCIENCE
Citation: Use Of Cystatin C And Serum Creatinine For The Diagnosis Of Contrast-induced Nephropathy In Patients Undergoing Contrast-enhanced Computed Tomography At An Oncology Centre. Public Library Science, v. 10, p. MAY-2015.
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0122877
Address: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122877
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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