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|Type:||Artigo de periódico|
|Title:||Is the Immunohistochemical Expression of Proliferation (Ki-67) and Apoptosis (Bcl-2) Markers and Cyclooxigenase-2 (COX-2) Related to Carcinogenesis in Postmenopausal Endometrial Polyps?|
|Author:||Antunes, Armando, Jr.|
Andrade, Liliana A. L. A.
Pinto, Glauce A.
Pinto-Neto, Aarao M.
|Abstract:||OBJECTIVE: To evaluate the pattern of Ki-67, Bcl-2 and COX-2 expression in the glandular epithelium and stroma of malignant and benign endometrial polyps in post-menopause. STUDY DESIGN: A total of 390 postmenopausal women underwent surgical hysteroscopy; women with endometrial polyps were included. Polypoid lesions were histologically classified as benign, premalignant or malignant lesions. Ki-67, Bcl-2 and COX-2 expression were evaluated by immunohistochemistry according to percentage of stained cells, staining intensity, and final score. RESULTS: The prevalence of malignancy in endometrial polyps was 7.1% and was associated with postmenopausal bleeding. The final score showed that only mean COX-2 expression was higher in malignant polyps both in the glandular epithelium (6.1 +/- 2.5) (p < 0.001) and stroma (2.4 +/- 3.0) (p < 0.01). There was a higher Bcl-2 expression, especially in the glandular epithelium, with no differences between benign polyps and premalignant/malignant polyps. Ki-67 expression was low in both benign polyps and premalignant/malignant polyps. CONCLUSION: Polyps in postmenopause have a high COX-2 expression that is higher in malignant polyps than in benign polyps. There was no difference in Ki-67 and Bcl-2 expression between malignant polyps and premalignant/malignant polyps. (Anal Quant Cytopathol Histopathol 2012;34:264-272)|
|Editor:||Sci Printers & Publ Inc|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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