Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242298
Type: Artigo de periódico
Title: Unraveling The Biosynthesis Of Pilocarpine In Pilocarpus Microphyllus
Author: Christine
Alexandra; Sawaya
Helena Frankland; Costa
Yanna Dias; Mazzafera
Paulo
Abstract: Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids related to pilocarpine have been reported in the previous years, little is still known about its biosynthetic route. At most, histidine has been reported as the precursor of pilocarpine. Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllophiline and anhydropilosine) were supplied to P. microphyllus leaves and the alkaloid profile analyzed by UPLC-MS, we suggest a biosynthesis pathway for pilocarpine. Further experiments using labeled precursors associated with transcriptome data may allow us to understand the whole biosynthesis pathway and its genetic control.
Subject: Imidazole Alkaloids
Cell-suspension
Jaborandi
Plants
Caffeine
Cultures
Country: WESTERVILLE
Editor: NATURAL PRODUCTS INC
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/26058143
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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