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Type: Artigo de periódico
Title: Glycine Improves Biochemical And Biomechanical Properties Following Inflammation Of The Achilles Tendon
Author: Vieira
Cristiano Pedrozo; De Oliveira
Leticia Prado; Guerra
Flavia Da Re; De Almeida
Marcos Dos Santos; Cintra Gomes Marcondes
Maria Cristina; Pimentel
Edson Rosa
Abstract: Tendinopathy of the Achilles tendon is a clinical problem that motivates the scientific community to search for treatments that assist in restoring its functional properties. Glycine has broad biological effects, acting as a modulator of the inflammatory cascade, and is the predominant amino acid in collagen. A 5% glycine diet provided beneficial effects against toxicity and inflammation since glycine may restructure the collagen molecules faster due to its broad anti-inflammatory effects. The purpose was analyze the effects of a 5% glycine diet in rats as a treatment for the inflammatory process. The experimental groups were as follows: C (control group), G1 and G3 (inflammatory group), and G2 and G4 (glycine + inflammatory group). G1 and G2 were euthanized 8 days following injury, and G3 and G4 were euthanized 22 days following injury. The concentrations of hydroxyproline, non-collagenous proteins, and glycosaminoglycans, as well as the activity of MMP-2 and -9 were analyzed. Biomechanical and morphological tests were employed. Higher concentrations of hydroxyproline and glycosaminoglycans were found in G4 and an increased activity of MMP-2 was found in G2. Higher birefringence was noted in group G2. The biomechanical results indicated that the tendon was more resistant to loading to rupture upon treatment with a glycine diet in group G4. Glycine induced the synthesis of important components of the tendon. A rapid remodeling was noted when compared with the inflamed-only groups. These data suggest that glycine may be a beneficial supplement for individuals with inflammation of the Achilles tendon. (C) 2014 Wiley Periodicals, Inc.
Subject: Digital Flexor Tendon
Country: HOBOKEN
Citation: Glycine Improves Biochemical And Biomechanical Properties Following Inflammation Of The Achilles Tendon. Wiley-blackwell, v. 298, p. 538-545 MAR-2015.
Rights: fechado
Identifier DOI: 10.1002/ar.23041
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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