Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242149
Type: Artigo
Title: Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis
Author: Cavalcante, Walter Luís Garrido
Ponce-Soto, Luis Alberto
Marangoni, Sérgio
Gallacci, Márcia
Abstract: A myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation. It was concluded that both venoms present neurotoxic activity as a consequence of their crotoxin content. Furthermore, crotoxin from C.d. cumanensis is more potent than that from C.d. ruruima venom. At the concentration range in which both venoms express neurotoxic activity, only C.d. cumanensis venom also manifest a direct myotoxic effect that probably involves the synergic participation of other components than crotoxin. (C) 2015 Elsevier Ltd. All rights reserved.
A myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation. It was concluded that both venoms present neurotoxic activity as a consequence of their crotoxin content. Furthermore, crotoxin from C.d. cumanensis is more potent than that from C.d. ruruima venom. At the concentration range in which both venoms express neurotoxic activity, only C.d. cumanensis venom also manifest a direct myotoxic effect that probably involves the synergic participation of other components than crotoxin.
Subject: Transmissão neuromuscular
Venenos de serpentes
Agentes neurotoxicos
Crotalus
Country: Reino Unido
Editor: Elsevier
Citation: Neuromuscular Effects Of Venoms And Crotoxin-like Proteins From Crotalus Durissus Ruruima And Crotalus Durissus Cumanensis. Pergamon-elsevier Science Ltd, v. 96, p. 46-49 MAR-2015.
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2015.01.006
Address: https://www.sciencedirect.com/science/article/pii/S0041010115000094
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos

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