Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242078
Type: Artigo de periódico
Title: Development Of Silk Fibroin/nanohydroxyapatite Composite Hydrogels For Bone Tissue Engineering
Author: Ribeiro
Marta; de Moraes
Mariana A.; Beppu
Marisa M.; Garcia
Monica P.; Fernandes
Maria H.; Monteiro
Fernando J.; Ferraz
Maria P.
Abstract: This work presents a novel composite hydrogel consisting of silk fibroin (SF) and nanohy-droxyapatite (nanoHA) prepared by a new and innovative method using ethanol as gelling agent capable of forming hydrogels in few minutes. The properties of the composite material, such as the microstructure as well as the chemical, and physical properties were studied. Moreover in vitro studies of osteoblastic citocompatibility were performed. The microporosity and macroporosity obtained combined with interconnected porous structure and a uniform dispersion of nanoHA particles throughout the fibroin matrix makes composite hydrogel suitable for bone regeneration. The compression modulus of composite hydrogels was increased as the nanoHA concentration increased from 10 to 15 wt.% and the water uptake ability of these materials decreased with the incorporation of nanoHA. The metabolic and alkaline phosphatase activities of osteoblastic cells were improved with the incorporation of nanoHA in the SF matrix providing a more promising material for bone tissue engineering. (C) 2015 Elsevier Ltd. All rights reserved.
Subject: Porous Hydroxyapatite
Drug-delivery
In-vitro
Scaffolds
Fibroin
Films
Biomaterials
Chitosan
Osteoblasts
Temperature
Country: OXFORD
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Citation: Development Of Silk Fibroin/nanohydroxyapatite Composite Hydrogels For Bone Tissue Engineering. Pergamon-elsevier Science Ltd, v. 67, p. 66-77 JUN-2015.
Rights: embargo
Identifier DOI: 10.1016/j.eurpolymj.2015.03.056
Address: http://www.sciencedirect.com/science/article/pii/S0014305715001913
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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