Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242007
Type: Artigo de periódico
Title: The S6k Protein Family In Health And Disease
Author: Tavares
Mariana R.; Pavan
Isadora C. B.; Amaral
Camila L.; Meneguello
Leticia; Luchessi
Augusto D.; Simabuco
Fernando M.
Abstract: The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis stimulates protein synthesis and cell growth. S6K1 has two well-known isoforms, p70-S6K1 and p85-S6K1, generated by alternative translation initiation sites. A third isoform, named p31-S6K1, has been characterized as a truncated type of the protein due to alternative splicing, and reports have shown its important role in cancer. Studies involving S6K2 are scarce. This article aims to review what is new in the literature about these kinases and establish differences regarding their interacting proteins, activation and function, connecting their roles in the homeostasis of the cell and in pathological conditions. (C) 2015 Elsevier Inc. All rights reserved.
Subject: Endothelial-cell Senescence
Human Breast-tumors
Raw 264.7 Cells
Mammalian Target
L-arginine
Kinase 2
Immunohistochemical Analysis
Parkinsons-disease
P70s6 Kinase
Nitric-oxide
Country: OXFORD
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Citation: The S6k Protein Family In Health And Disease. Pergamon-elsevier Science Ltd, v. 131, p. 1-10 Jun-2015.
Rights: embargo
Identifier DOI: 10.1016/j.lfs.2015.03.001
Address: http://www.sciencedirect.com/science/article/pii/S0024320515001538
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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