Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/242
Type: Artigo de periódico
Title: In utero protein restriction causes growth delay and alters sperm parameters in adult male rats
Author: TOLEDO, Fabiola C.
PEROBELLI, Juliana E.
PEDROSA, Flavia P. C.
ANSELMO-FRANCI, Janete A.
KEMPINAS, Wilma D. G.
Abstract: Background: Recent studies have supported the concept of ""fetal programming"" which suggests that during the intrauterine development the fetus may be programmed to develop diseases in adulthood. The possible effects of in utero protein restriction on sexual development of rat male offspring were evaluated in the present study. Methods: Pregnant Wistar rats were divided into two experimental groups: one group treated with standard chow (SC, n = 8, 17% protein) and the other group treated with hypoproteic chow (HC, n = 10, 6% protein) throughout gestation. After gestation the two experimental groups received standard chow. To evaluate the possible late reproductive effects of in utero protein restriction, the male offspring of both groups were assessed at different phases of sexual development: prepubertal (30 days old); peripubertal (60 days old); adult (90 days old). Student's t test and Mann-Whitney test were utilized. Differences were considered significant when p < 0.05. Results: We found that in utero protein restriction reduced the body weight of male pups on the first postnatal day and during the different sexual development phases (prepubertal, peripubertal and adult). During adulthood, Sertoli cell number, sperm motility and sperm counts in the testis and epididymal cauda were also reduced in HC. Furthermore, the numbers of sperm presenting morphological abnormalities and cytoplasmic drop retention were higher in HC. Conclusions: In conclusion, in utero protein restriction, under these experimental conditions, causes growth delay and alters male reproductive-system programming in rats, suggesting impairment of sperm quality in adulthood.
Country: Inglaterra
Editor: BIOMED CENTRAL LTD
Citation: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, v.9, 2011
Rights: aberto
Identifier DOI: 10.1186/1477-7827-9-94
Address: http://dx.doi.org/10.1186/1477-7827-9-94
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000292939400001&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2011
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

Files in This Item:
File Description SizeFormat 
art_TOLEDO_In_utero_protein_restriction_causes_growth_delay_2011.pdfpublished version1.24 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.