Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/24199
Type: Artigo de periódico
Title: Effects of caffeine on learning and memory in rats tested in the Morris water maze
Author: Angelucci, M.E.M.
Cesário, C.
Hiroi, R.H.
Rosalen, P.L.
Cunha, C. Da
Abstract: We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P<=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P<=0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature.
Subject: Memory
Learning
Caffeine
Methylxanthines
Adenosine receptor antagonist
Morris water maze
Editor: Associação Brasileira de Divulgação Científica
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2002001000013
Address: http://dx.doi.org/10.1590/S0100-879X2002001000013
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013
Date Issue: 1-Oct-2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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