Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241941
Type: Artigo de periódico
Title: Ritualistic Use Of Ayahuasca Versus Street Use Of Similar Substances Seized By The Police: A Key Factor Involved In The Potential For Intoxications And Overdose?
Author: Lanaro
Rafael; de Aquino Calemi
Debora Bressanim; Togni
Loraine Rezende; Costa
Jose Luiz; Yonamine
Mauricio; Santos Cazenave
Silvia de Oliveira; Linardi
Alessandra
Abstract: The ritualistic use of ayahuasca is becoming a global phenomenon. This beverage contains a combination of monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) and N,N-dimethyltryptamine, the main substance responsible for its visionary effect. The recreational use of similar alkaloids and N,N-dimethyltryptamine has increased in recent years, mainly because of their hallucinogenic effects. In the present study, the concentrations of psychoactive alkaloids in three powder samples seized by the Sao Paulo State Police and nine ayahuasca aqueous extracts were analyzed by HPLC-DAD in an attempt to distinguish between illicit drugs and the religious beverage. The alkaloids detected (mu g/mL) in the ayahuasca aqueous extracts were N,N-dimethyltryptamine (402-2070.3), harmaline (27.5-181.3), harmine (294.5-2893.8), and tetrahydroharmine (849.5-2052.5), whereas, of the three powder samples, one contained only N,N-dimethyltryptamine (82% and 2% w/w, respectively) while the other contained only harmaline (16%, w/w) and harmine (12%, w/w). The ritualistic use of ayahuasca involves oral intake and the probability of overdose is minimized by serotonergic stimulation of vagal pathways, leading to vomiting and diarrhea. In contrast, the recreational use of N,N-dimethyltryptamine involves consumption mainly by smoking or inhalation, both of which markedly increase its bioavailability and the potential for intoxications.
Subject: Beta-carboline Alkaloids
Dimethyltryptamine Dmt
Harmala Alkaloids
Human Plasma
N,n-dimethyltryptamine
Internet
Humans
5-methoxy-n,n-dimethyltryptamine
Pharmacology
Challenges
Country: ABINGDON
Editor: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Citation: Ritualistic Use Of Ayahuasca Versus Street Use Of Similar Substances Seized By The Police: A Key Factor Involved In The Potential For Intoxications And Overdose?. Routledge Journals, Taylor & Francis Ltd, v. 47, p. 132-139 Mar-2015.
Rights: embargo
Identifier DOI: 10.1080/02791072.2015.1013202
Address: http://www.tandfonline.com/doi/abs/10.1080/02791072.2015.1013202?journalCode=ujpd20#.VytHKNIrLcc
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.