Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241919
Type: Artigo de periódico
Title: Sorbitol-plasticized And Neutralized Chitosan Membranes As Skin Substitutes
Author: Nogueira Campos
Maria Gabriela; Innocentini Mei
Lucia Helena; Santos
Arnaldo Rodrigues
Jr.
Abstract: Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na2CO3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation.
Subject: Tissue Engineering Applications
In-vitro
Scaffolds
Chitin
Fibroblasts
Films
Proliferation
Derivatives
Surface
Cells
Country: SAO CARLOS
Editor: UNIV FED SAO CARLOS, DEPT ENGENHARIA MATERIALS
Citation: Sorbitol-plasticized And Neutralized Chitosan Membranes As Skin Substitutes. Univ Fed Sao Carlos, Dept Engenharia Materials, v. 18, p. 781-790 JUL-AUG-2015.
Rights: fechado
Identifier DOI: 10.1590/1516-1439.025015
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392015000400781&lng=en&nrm=iso&tlng=en
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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