Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241917
Type: Artigo de periódico
Title: Peri-intraventricular Hemorrhage And Oxidative And Inflammatory Stress Markers In Very-low Birth Weight Newborns
Author: Caldas
Jamil P. S.; Braghini
Carolina A.; Mazzola
Tais N.; Vilela
Maria M. S.; Marba
Sergio T. M.
Abstract: Objectives: To evaluate the association between oxidative and inflammatory stress markers with peri-intraventricular hemorrhage (PIVH) in very-low birth weight newborns. Methods: This was a prospective study conducted in a level III neonatal unit. Basal and stimulated reactive oxygen intermediates (ROls), reduced glutathione (GSH), and interleukin-6 (IL-6) levels were measured in umbilical cord blood. Newborns underwent serial ultrasound at the bedside, at 6, 12, 24, and 72 hours of life and at seven days for the diagnosis of PIVH, classified as grades I to IV. Two groups were assessed, those with and without PIVH; maternal and neonatal control variables were used for comparison. Univariate and multiple regression analyses were applied. Results: A total of 125 newborns were assessed. PIVH incidence rate was 12.0%. In the univariate analysis, basal ROI, the use of two or more doses of corticosteroids, birth weight < 1,000g, ventilatory support use, and SNAPPE II value >= 22 were significantly associated with PIVH. However, in the multivariate analysis, only antenatal steroid use was independently associated with the disease (OR 0,194; 95% CI: 0,048 to 0,773; p=0,02). Conclusion: ROI, GSH, and IL-6 levels were not associated with the occurrence of PIVH in very-low birth weight infants (C) 2015 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
Subject: Beagle Puppy Model
Intraventricular Hemorrhage
Cord Blood
Premature-infants
Histologic Chorioamnionitis
Respiratory Burst
Preterm Newborn
Whole-blood
Interleukin-6
Cytokines
Country: RIO DE JANEIRO, RJ
Editor: SOC BRASIL PEDIATRIA
Rights: fechado
Identifier DOI: 10.1016/j.jped.2014.09.008
Address: http://www.sciencedirect.com/science/article/pii/S0021755715000431
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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