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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAltered Expression Of Hyaluronan, Has1-2, And Hyal1-2 In Oral Lichen Planuspt_BR
dc.contributor.authorSiponenpt_BR
dc.contributor.authorMaria; Kullaapt_BR
dc.contributor.authorArja; Nieminenpt_BR
dc.contributor.authorPentti; Salopt_BR
dc.contributor.authorTuula; Pasonen-Seppanenpt_BR
dc.contributor.authorSannapt_BR
unicamp.author.emailmariasiponen@yahoo.compt_BR
unicamp.author[Salo, Tuula] Univ Estadual Campinas, Piracicaba Dent Sch, Grad Program Estomatopatol, Piracicaba Sao Paulo, Brazilpt_BR
unicamp.author.external[Siponen, Mariapt
unicamp.author.externalKullaa, Arjapt
unicamp.author.externalSalo, Tuula] Univ Oulu, Inst Dent, Dept Diagnost & Oral Med, Oulu 90014, Finlandpt
unicamp.author.external[Siponen, Maria] Kuopio Univ Hosp, Dept Oral & Maxillofacial Dis, SF-70210 Kuopio, Finlandpt
unicamp.author.external[Kullaa, Arja] Hlth Ctr Oulu, Educ Dent Clin, Oulu, Finlandpt
unicamp.author.external[Nieminen, Pentti] Univ Oulu, Med Informat & Stat Res Grp, Fac Med, Oulu 90014, Finlandpt
unicamp.author.external[Salo, Tuula] Oulu Univ Hosp, Med Res Ctr, Oulu, Finlandpt
unicamp.author.external[Salo, Tuula] Univ Helsinki, Inst Dent, Helsinki, Finlandpt
unicamp.author.external[Pasonen-Seppanen, Sanna] Univ Eastern Finland, Inst Biomed, Sch Med, Fac Hlth Sci, Kuopio, Finlandpt
dc.subjectSquamous-cell Carcinomaspt_BR
dc.subjectToll-like Receptor-4pt_BR
dc.subjectEpithelial-cellspt_BR
dc.subjectDendritic Cellspt_BR
dc.subjectMouse Epidermispt_BR
dc.subjectCd44pt_BR
dc.subjectSynthasept_BR
dc.subjectLocalizationpt_BR
dc.subjectInflammationpt_BR
dc.subjectCatabolismpt_BR
dc.description.abstractBackgroundOral lichen planus (OLP) is an immune-mediated mucosal disease of unclear etiology and of unresolved pathogenesis. Hyaluronan (HA) is an extracellular matrix glycosaminoglycan involved in inflammation and tumor progression. However, its presence in OLP has not been reported. We therefore aimed to study the immunohistochemical expression of HA, its receptor CD44, hyaluronan synthases (HAS1-3), and hyaluronidases (HYAL1-2) in OLP. MethodsThe presence of HA, CD44, HAS1-3, and HYAL1-2 was studied by immunohistochemical methods in 55 OLP and 23 control oral mucosal specimens (CTR). The localization, intensity, and differences of the epithelial expression between OLP and CTRs were analyzed. ResultsHA and CD44 were found on cell membranes in the epithelial basal and intermediate layers in CTR and OLP specimens. The HA staining intensity was stronger in the basal layer of the epithelium in OLP than in CTRs (P<0.001). HAS1 (P=0.001) and HAS2 (P<0.001) showed stronger staining in the basal and weaker staining in the superficial (P<0.001) epithelial layers in OLP than in CTRs. The immunostaining of HAS3 was low in both OLP and CTRs. Positive HYAL1 and HYAL2 staining were mainly found in the basal and intermediate epithelial layers, and their intensities were significantly increased in OLP, except HYAL 2 in the intermediate epithelial layer. ConclusionsHA, HAS1-2, and HYAL1-2 have altered expression in OLP compared to CTRs and may therefore have a role in OLP pathogenesis.en
dc.relation.ispartofJOURNAL OF ORAL PATHOLOGY & MEDICINEpt_BR
dc.publisher.countryHOBOKENpt_BR
dc.publisherWILEY-BLACKWELLpt_BR
dc.date.issued2015-JULpt_BR
dc.identifier.citationAltered Expression Of Hyaluronan, Has1-2, And Hyal1-2 In Oral Lichen Planus. Wiley-blackwell, v. 44, p. 401-409 JUL-2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume44pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage401pt_BR
dc.description.lastpage409pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.wosidWOS:000357524000002pt_BR
dc.identifier.doi10.1111/jop.12294pt_BR
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/jop.12294/abstractpt_BR
dc.description.sponsorshipAcademy of Finlandpt_BR
dc.description.sponsorshipEVO funds of Kuopio University Hospitalpt_BR
dc.description.sponsorshipSpearhead Funds of the University of Eastern Finland/the Cancer Center of Eastern Finlandpt_BR
dc.description.sponsorshipSigrid Juselius Foundationpt_BR
dc.date.available2016-06-07T13:15:34Z-
dc.date.accessioned2016-06-07T13:15:34Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:15:34Z (GMT). No. of bitstreams: 1 wos_000357524000002.pdf: 1166406 bytes, checksum: 70973be6bf91a0271de9fe9f23fc4a08 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241904-
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