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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleChitosan-alginate Membranes Accelerate Wound Healingpt_BR
dc.contributor.authorCaetanopt_BR
dc.contributor.authorGuilherme Ferreira; Cipriani Fradept_BR
dc.contributor.authorMarco Andrey; Moretti Andradept_BR
dc.contributor.authorThiago Antonio; Leitept_BR
dc.contributor.authorMarcel Nani; Buenopt_BR
dc.contributor.authorCecilia Zorzi; Moraespt_BR
dc.contributor.authorAngela Maria; Ribeiro-Paespt_BR
dc.contributor.authorJoao Tadeupt_BR
unicamp.author.emailjtrpaes@yahoo.com.brpt_BR
unicamp.authorMoraes, Angela Maria] Univ Estadual Campinas, Sch Chem Engn, Dept Engn Mat & Bioproc, Sao Paulo, Brazilpt_BR
unicamp.author.external[Caetano, Guilherme Ferreira] Univ Sao Paulo, Inst Biomed Sci, Biotecnol Post Grad Program, Sao Paulo, Brazilpt
unicamp.author.external[Cipriani Frade, Marco Andreypt
unicamp.author.externalMoretti Andrade, Thiago Antoniopt
unicamp.author.externalLeite, Marcel Nani] Univ Sao Paulo, Dept Internal Med, Div Dermatol, Ribeirao Preto Sch Med, Sao Paulo, Brazilpt
unicamp.author.external[Bueno, Cecilia Zorzipt
unicamp.author.external[Ribeiro-Paes, Joao Tadeu] Sao Paulo State Univ UNESP, Dept Biol, Sao Paulo, Brazilpt
dc.subjectIn-vitropt_BR
dc.subjectBiomedical Applicationspt_BR
dc.subjectDressingspt_BR
dc.subjectSkinpt_BR
dc.subjectDeliverypt_BR
dc.subjectUlcerspt_BR
dc.subjectRepairpt_BR
dc.subjectBeadspt_BR
dc.subjectFilmpt_BR
dc.description.abstractThe purpose of this study was to evaluate the efficacy of chitosan-alginate membrane to accelerate wound healing in experimental cutaneous wounds. Two wounds were performed in Wistar rats by punching (1.5 cm diameter), treated with membranes moistened with saline solution (CAM group) or with saline only (SL group). After 2, 7, 14, and 21 days of surgery, five rats of each group were euthanized and reepithelialization was evaluated. The wounds/scars were harvested for histological, flow cytometry, neutrophil infiltrate, and hydroxyproline analysis. CAM group presented higher inflammatory cells recruitment as compared to SL group on 2(nd) day. On the 7(th) day, CAM group showed higher CD11b(+) level and lower of neutrophils than SL group. The CAM group presented higher CD4(+) cells influx than SL group on 2(nd) day, but it decreased during the follow up and became lower on 14(th) and 21(st) days. Higher fibroplasia was noticed on days 7 and 14 as well as higher collagenesis on 21(st) in the CAM group in comparison to SL group. CAM group showed faster reepithelialization on 7(th) day than SL group, although similar in other days. In conclusion, chitosan-alginate membrane modulated the inflammatory phase, stimulated fibroplasia and collagenesis, accelerating wound healing process in rats. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1013-1022, 2015.en
dc.relation.ispartofJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALSpt_BR
dc.publisher.countryHOBOKENpt_BR
dc.publisherWILEY-BLACKWELLpt_BR
dc.date.issued2015-JULpt_BR
dc.identifier.citationChitosan-alginate Membranes Accelerate Wound Healing. Wiley-blackwell, v. 103, p. 1013-1022 JUL-2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume103pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage1013pt_BR
dc.description.lastpage1022pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1552-4973pt_BR
dc.identifier.wosidWOS:000356671800007pt_BR
dc.identifier.doi10.1002/jbm.b.33277pt_BR
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33277/abstract;jsessionid=33D6D88F75F8C97E81183D2DB3D3BF92.f02t04pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFAEPA-HCFMRP-USPpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2016-06-07T13:15:17Z-
dc.date.accessioned2016-06-07T13:15:17Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:15:17Z (GMT). No. of bitstreams: 1 wos_000356671800007.pdf: 816264 bytes, checksum: 7d4e8e7ba0a97ad3292c73c3b189e102 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241836-
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