Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241793
Type: Artigo de periódico
Title: A Novel Dosage Form For Buccal Administration Of Bupropion
Author: Galvao Almeida
Nilsa Maria; Lima
Renata; Ribeiro Alves
Thais Francine; Rebelo
Marcia de Araujo; Severino
Patricia; Chaud
Marco Vinicius
Abstract: Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm(2). The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking.
Subject: In-vitro Characterization
Smoking-cessation
Cardiovascular-disease
Bioadhesive Films
Delivery-system
Nicotine Patch
Formulation
Vivo
Insulin
Trial
Country: SAO PAULO
Editor: UNIV SAO PAULO, CONJUNTO QUIMICAS
Citation: A Novel Dosage Form For Buccal Administration Of Bupropion. Univ Sao Paulo, Conjunto Quimicas, v. 51, p. 91-100 JAN-MAR-2015.
Rights: aberto
Identifier DOI: 10.1590/S1984-82502015000100010
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100091&lng=en&nrm=iso&tlng=en
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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