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Type: Artigo de periódico
Title: Relaxant Effect Of A Metal-based Drug In Human Corpora Cavernosa And Its Mechanism Of Action
Author: Leitao Junior
A. S.; Campos
R. M.; Cerqueira
J. B. G.; Fonteles
M. C.; Santos
C. F.; de Nucci
G.; Sousa
E. H. S.; Lopes
L. G. F.; Gonzaga-Silva
L. F.; Nascimento
N. R. F.
Abstract: We studied the mechanisms involved in the human corpora Cavernosa (HCC) relaxation induced by a new metal-based nitric oxide (NO) donor, the ruthenium complex ciS-[Ru(bpy)(2)lmn(NO)](+3) (FOR0811). FOR0811 produced relaxation in phenylephrine (PE)-precontracted HCC with a maximal response that achieved 112.9 +/- 10.6%. There was no difference between the maximal relaxation induced by FOR0811 When compared with sodium nitroprusside (SNP) (106:8 +/- 7.3%), BAY41-2272 (107.6 +/- 4.1%) or vardenafil (103.4 +/- 3.8%), however, FOR0811 was less potent than SNP and vardenafil. L-N-G-nitroarginine methyl ester (L-NAME), a NO synthase inhibitor, had no effect in the concentration response curve elicited by FOR0811. 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a heme-Site inhibitor of soluble guanylyl cyclase (sGC) was able to either block or reverse the relaxation induced by FOR0811. On the other band, the relaxation induced by FOR0811 was not affected by glibenclamide, a blocker Of ATP-sensitive potassium channels: FOR0811 (10 mu M) Was able to increase cyclic guanosine monophosphate (CGMP) levels in corpora cavernosa strips. FOR0811 completely relaxes HCC by a sGC-cGMP-dependent mechanism and can be a lead compound in the development of new stable NO donors.
Subject: Soluble Guanylate-cyclase
Rabbit Corpus Cavernosum
Nitric-oxide Donors
Erectile Dysfunction
Ruthenium Complex
Penile Erection
Country: LONDON
Citation: Relaxant Effect Of A Metal-based Drug In Human Corpora Cavernosa And Its Mechanism Of Action. Nature Publishing Group, v. 28, p. 20-24 JAN-FEB-2016.
Rights: fechado
Identifier DOI: 10.1038/ijir.2015.27
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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