Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241593
Type: Artigo de periódico
Title: Follicular Fluid Lipid Fingerprinting From Women With Pcos And Hyper Response During Ivf Treatment
Author: Cordeiro
Fernanda Bertuccez; Cataldi
Thais Regiani; Teixeira da Costa
Livia do Vale; de Lima
Camila Bruna; Stevanato
Juliana; Zylbersztejn
Daniel Suslik; Ferreira
Christina Ramires; Eberlin
Marcos Nogueira; Cedenho
Agnaldo Pereira; Lo Turco
Edson Guimaraes
Abstract: Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder that leads to lower natural reproductive potential and presents a challenge for assisted reproductive medicine because patients may exhibit immature oocyte retrieval and a higher risk of ovarian hyper stimulation syndrome during in vitro fertilization (IVF) treatment. This study aimed to identify potential lipid biomarkers for women with PCOS and a hyper response to controlled ovarian stimulation. Follicular fluid samples were collected from patients who underwent IVF, including normal responder women who became pregnant (control group, n = 11), women with PCOS and a hyper response to gonadotropins (PCOS group, n = 7) and women with only hyper response to gonadotropins (HR group, n = 7). A lipidomic analysis was performed by electrospray ionization mass spectrometry, and candidate biomarkers were analyzed by tandem mass spectrometry experiment. The lipid profiles indicated particularities related to differences in phosphatidylcholine (PCOS and HR), phosphatidylserine, phosphatydilinositol and phosphatidylglycerol (control), sphingolipids (PCOS) and phosphatidylethanolamine (control and HR). These findings contribute to the understanding of the molecular mechanisms associated with lipid metabolism in the PCOS-related hyper response, and strongly suggest that these lipids may be useful as biomarkers, leading to the development of more individualized treatment for pregnancy outcome.
Subject: Polycystic-ovary-syndrome
Mass-spectrometry
2003 Consensus
Phosphatidylserine
Cells
Sphingolipids
Biosynthesis
Redistribution
Fertilization
Phospholipids
Country: NEW YORK
Editor: SPRINGER/PLENUM PUBLISHERS
Rights: fechado
Identifier DOI: 10.1007/s10815-014-0375-0
Address: http://link.springer.com/article/10.1007%2Fs10815-014-0375-0
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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