Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/241593
Type: Artigo
Title: Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment
Author: Cordeiro, Fernanda Bertuccez
Cataldi, Thaís Regiani
Costa, Lívia do Vale Teixeira da
Lima, Camila Bruna de
Stevanato, Juliana
Zylbersztejn, Daniel Suslik
Ferreira, Christina Ramires
Eberlin, Marcos Nogueira
Cedenho, Agnaldo Pereira
Abstract: Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder that leads to lower natural reproductive potential and presents a challenge for assisted reproductive medicine because patients may exhibit immature oocyte retrieval and a higher risk of ovarian hyper stimulation syndrome during in vitro fertilization (IVF) treatment. This study aimed to identify potential lipid biomarkers for women with PCOS and a hyper response to controlled ovarian stimulation. Follicular fluid samples were collected from patients who underwent IVF, including normal responder women who became pregnant (control group, n = 11), women with PCOS and a hyper response to gonadotropins (PCOS group, n = 7) and women with only hyper response to gonadotropins (HR group, n = 7). A lipidomic analysis was performed by electrospray ionization mass spectrometry, and candidate biomarkers were analyzed by tandem mass spectrometry experiment. The lipid profiles indicated particularities related to differences in phosphatidylcholine (PCOS and HR), phosphatidylserine, phosphatydilinositol and phosphatidylglycerol (control), sphingolipids (PCOS) and phosphatidylethanolamine (control and HR). These findings contribute to the understanding of the molecular mechanisms associated with lipid metabolism in the PCOS-related hyper response, and strongly suggest that these lipids may be useful as biomarkers, leading to the development of more individualized treatment for pregnancy outcome.
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder that leads to lower natural reproductive potential and presents a challenge for assisted reproductive medicine because patients may exhibit immature oocyte retrieval and a higher risk of
Subject: Síndrome do ovário policístico
Lipídeos
ESI-MS
Country: Estados Unidos
Editor: Springer
Citation: Follicular Fluid Lipid Fingerprinting From Women With Pcos And Hyper Response During Ivf Treatment. Springer/plenum Publishers, v. 32, p. 45-54 JAN-2015.
Rights: fechado
Fechado
Identifier DOI: 10.1007/s10815-014-0375-0
Address: https://link.springer.com/article/10.1007/s10815-014-0375-0
Date Issue: 2014
Appears in Collections:IQ - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000347949800006.pdf1.13 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.