Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/24159
Type: Artigo de periódico
Title: Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases
Author: Boechat, L.H.B.
Zollner, R.L.
Abstract: Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to serum from patients with autoimmune (Graves' disease and Hashimoto's thyroiditis) and non-autoimmune (subacute thyroiditis) disease. The results showed no difference in frequency of recognition of any peptide by sera from patients with autoimmune thyroiditis. In contrast, sera from patients with subacute thyroiditis reacted more frequently with a peptide of 80 kDa. These results suggest the presence of antibody subpopulations directed at fragments produced in vivo by enzymatic cleavage of thyroglobulin. This fragment and antibodies to it may represent markers for subacute thyroiditis.
Subject: autoantibodies
autoimmunity
thyroglobulin
trypsin
thyroiditis
proteases
Editor: Associação Brasileira de Divulgação Científica
Rights: aberto
Identifier DOI: 10.1590/S0100-879X1999000400012
Address: http://dx.doi.org/10.1590/S0100-879X1999000400012
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400012
Date Issue: 1-Apr-1999
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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