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Type: Artigo de periódico
Title: Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes
Title Alternative: Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark
Author: Santos, Érica L.
Costa, Emmanoel V.
Marques, Francisco A.
Vaz, Nelissa P.
Maia, Beatriz Helena L. N. Sales
Magalhães, Eva G.
Tozzi, Ana Maria A.
Abstract: The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.
Subject: Lonchocarpus filipes
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422009000900002
Date Issue: 1-Jan-2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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