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Type: Artigo de periódico
Title: Efeito da adição de precursores na produção de alcaloide anticancerígeno usando a técnica de planejamento experimental
Title Alternative: Effect of the precursor addition on the anticancer alkaloid production using experimental design methodology
Author: Justo, Oselys Rodriguez
Haber-Perez, Victor
Viana, Cláudia de Oliveira
Alegre, Ranulfo Monte
Abstract: The effect of precursors on the anticancer alkaloid production by submerged fermentation using M. anisopliae 3935 was studied, according to complete experimental design 2² with three central points. The results showed that lysine was the most important variable, however, when both lysine and glucose were added to the fermentation medium, the alkaloid production reached, approximately, 17 mg L-1 after 120 hours of fermentation. Then, the scale-up of the process was carried out and these results were confirmed. Finally, 35 mg L-1 of alkaloid at 192 h were attained after increment of added aminoacid lysine.
Subject: alkaloid
M. anisopliae
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422009000600006
Date Issue: 1-Jan-2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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