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|Type:||Artigo de periódico|
|Title:||Factors Impacting The Growth And Nutritional Status Of Cystic Fibrosis Patients Younger Than 10 Years Of Age Who Did Not Undergo Neonatal Screening [fatores Que Afetam O Crescimento E Estado Nutricional De Pacientes Com Fibrose Cística Com Idade Inferior A 10 Anos E Que Não Foram Submetidos à Triagem Neonatal]|
|Abstract:||Objective The aim of this study was to evaluate by clinical and laboratory parameters how cystic fibrosis (CF) affects growth and nutritional status of children who were undergoing CF treatment but did not receive newborn screening. Methods A historical cohort study of 52 CF patients younger than 10 years of age were followed in a reference center in Campinas, Southeast Brazil. Anthropometric measurements were abstracted from medical records until March/2010, when neonatal screening program was implemented. Between September/2009 and March/2010, parental height of the 52 CF patients were also measured. Results Regarding nutritional status, four patients had Z-scores ≤ -2 for height/age (H/A) and body mass index/age (BMI/A). The following variables were associated with improved H/A ratio: fewer hospitalizations, longer time from first appointment to diagnosis, longer time from birth to diagnosis and later onset of respiratory disease. Forced vital capacity [FVC(%)], forced expiratory flow between 25-75% of FVC [FEF25-75(%)], forced expiratory volume in the first second [FEV1(%)], gestational age, birth weight and early respiratory symptoms were associated with IMC/A. Conclusions Greater number of hospitalizations, diagnosis delay and early onset of respiratory disease had a negative impact on growth. Lower spirometric values, lower gestational age, lower birth weight, and early onset of respiratory symptoms had negative impact on nutritional status. Malnutrition was observed in 7.7% of cases, but 23% of children had nutritional risk. © 2014 Associaçõ de Pediatria de São Paulo.|
|Editor:||Sao Paulo Pediatric Society|
|Citation:||Revista Paulista De Pediatria. Sao Paulo Pediatric Society, v. 33, n. 1, p. 3 - 11, 2015.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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