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Type: Artigo de periódico
Title: Separação cromatográfica quiral de anestésicos a partir de soluções diluídas e concentradas em escala preparativa
Title Alternative: Chiral chromatographic separation of anesthetics from dilute and concentrated solutions under preparative scale
Author: Silva Jr., Ivanildo José da
Barreto Jr., Amaro Gomes
Santana, Cesar Costapinto
Abstract: In this work the separation of the chiral anesthetic compounds ketamine and bupivacaine was development using two chiral stationary phases (CSP). Ketamine enantiomers were well separate in the polysaccharide-based CSP (microcrystalline cellulose triacetate - MCTA) while bupivacaine in the tartardiamide-based CSP (Kromasil CHI-TBB). In both cases, the effect of temperature was investigated under analytical conditions. An improvement in the separation performance with temperature was observed. Thermodynamic parameters were evaluated by the van't Hoff plot. We concluded that enthalpic effects controlled the retention in these chiral columns. The enantiomers of ketamine and bupivacaine were separated under overloaded conditions with a good performance.
Subject: enantiomer separation
chiral stationary phases
liquid chromatography
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422009000200017
Date Issue: 1-Jan-2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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