Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/238305
Type: Artigo
Title: Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study
Title Alternative: Efeito da associação ropivacaina-pancurÔnio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental
Author: Braga, Angelica de Fatima
Carvalho, Vanessa Henriques
Braga, Franklin Sarmento
Poterio, Gloria Maria Braga
Santos, Filipe Nadir Caparica
Abstract: Background and objectives: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to evaluate in vitro the interaction between ropivacaine and pancuronium, the influence on transmission and neuromuscular blockade, and the effectiveness of neostigmine and 4-aminopyridine to reverse the blockade. Methods: Rats were divided into groups (n=5) according to the study drug: ropivacaine (5μgmL-1); pancuronium (2μg.mL-1); ropivacaine+pancuronium. Neostigmine and 4-aminopyridine were used at concentrations of 2μgmL-1 and 20μgmL-1, respectively. The effects of ropivacaine on membrane potential and miniature end-plate potential, the amplitude of diaphragm responses before and 60minutes after the addition of ropivacaine (degree of neuromuscular blockade with pancuronium and with the association of pancuronium-ropivacaine), and the effectiveness of neostigmine and 4-aminopyridine on neuromuscular block reversal were evaluated. Results: Ropivacaine did not alter the amplitude of muscle response (the membrane potential), but decreased the frequency and amplitude of the miniature end-plate potential. Pancuronium blockade was potentiated by ropivacaine, and partially and fully reversed by neostigmine and 4-aminopyridine, respectively. Conclusions: Ropivacaine increased the neuromuscular block produced by pancuronium. The complete antagonism with 4-aminopyridine suggests presynaptic action of ropivacaine. © 2014 Sociedade Brasileira de Anestesiologia.
The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The a
metadata.dc.description.abstractalternative: Os efeitos dos anestésicos locais na junc ̧ão neuromuscular e suainfluência no bloqueio produzido por bloqueadores neuromusculares não-despolarizantes éainda alvo de pouca investigac ̧ão, no entanto esta interac ̧ão tem sido descrita em trabalhosexperimen
Subject: Anestésicos locais
Ropivacaina
Country: Países Baixos
Editor: Elsevier
Citation: Revista Brasileira De Anestesiologia. Elsevier Editora Ltda, v. 65, n. 2, p. 136 - 140, 2015.
Rights: fechado
Identifier DOI: 10.1016/j.bjan.2013.10.020
Address: https://www.sciencedirect.com/science/article/pii/S003470941400141X
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
2-s2.0-84922778660.pdf655.68 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.