Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/238097
Type: Artigo de periódico
Title: Stereoselective Bioreduction Of α-azido Ketones By Whole Cells Of Marine-derived Fungi
Abstract: Seven strains of marine-derived fungi (Aspergillus sclerotiorum CBMAI 849, Cladosporium cladosporioides CBMAI 857, Penicillium raistrickii CBMAI 931, Penicillium citrinum CBMA 1186, Mucor racemosus CBMAI 847, Beauveria felina CBMAI 738, and Penicillium oxalicum CBMAI 1185) and terrestrial fungus Penicillium chrysogenum CBMA1199 were screened as catalysts for the asymmetric reduction of α-keto azides 5–8 to their corresponding β-azidophenylethanols 9–12. The marine fungi showed Prelog and anti-Prelog selectivities to the reduction α-keto azides 5–8. The fungi A. sclerotiorum CBMAI 849, C. cladosporioides CBMAI 857, P. raistrickii CBMAI 931, and P. citrinum CBMA 1186 catalyzed the reduction of azido ketone 6 to the corresponding (R)-2-azido-1-(4-methoxyphenyl)ethanol (10) with good conversions (68–100 %) and excellent enantiomeric excesses (>99 % ee) according to Prelog rule. © 2015, Springer Science+Business Media New York.
Editor: Springer New York LLC
Rights: fechado
Identifier DOI: 10.1007/s10126-015-9644-x
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498362&partnerID=40&md5=6b997d6e3aae59263c364521395bb195
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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