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Type: Artigo de periódico
Title: Endothelial Nitric Oxide Synthase Genotypes Modulate Peripheral Vasodilatory Properties After Myocardial Infarction
Abstract: Background: Studies in population genetics suggest an important relationship between the eNOS G894T polymorphism and occurrence of acute myocardial infarction (AMI), with little known on its influence on the post-AMI period. Aim: To investigate the association of allelic variants produced by the G894T transversion in eNOS (rs1799983) with post-AMI variables. Methods: Cross-sectional analyses of anthropometric, clinical and laboratory assessments obtained within the first 24. h and after 5 and 30. days of the AMI event across T carriers and G homozygotes of eNOS in 371 consecutive cases of AMI with ST-segment elevation admitted to a Brazilian emergency service in cardiology. Genotypes were determined by polymerase chain reaction followed by enzymatic restriction. Results: Despite no difference between genotypic groups on aspects as Killip-Kimbal classification scores, extension of infarcted mass, lipid profile or pattern of medication use, an increase in serum nitric oxide from admission to day 5 was higher for T carriers (p < 0.001). Thirty days post-AMI, peripheral blood flow reserve was larger among T carriers either by flow- (p = 0.037) and nitrate-mediated (p = 0.040) dilation testing. Conclusion: Our results suggest an association of the eNOS 894T allele with an apparent improvement in late arterial function in post-AMI patients. © 2015 Elsevier B.V.
Editor: Elsevier
Citation: Gene. Elsevier, v. 568, n. 2, p. 165 - 169, 2015.
Rights: fechado
Identifier DOI: 10.1016/j.gene.2015.05.042
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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