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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAdministration of a murine diet supplemented with conjugated linoleic acid increases the expression and activity of hepatic uncoupling proteinspt_BR
dc.contributor.authorPereira, Amanda F.pt_BR
dc.contributor.authorSa, Larissa L.pt_BR
dc.contributor.authorReis, Felippe H. Z.pt_BR
dc.contributor.authorCardoso, Fernanda C.pt_BR
dc.contributor.authorAlberici, Rosana M.pt_BR
dc.contributor.authorPrado, Ieda M. R.pt_BR
dc.contributor.authorEberlin, Marcos N.pt_BR
dc.contributor.authorUyemura, Sergio A.pt_BR
dc.contributor.authorCurti, Carlospt_BR
dc.contributor.authorAlberici, Luciane C.pt_BR
unicamp.authorAlberici, Rosana M.pt_BR
unicamp.authorEberlin, Marcos N.pt_BR
unicamp.author.externalPereira, Amanda F.pt
unicamp.author.externalSa, Larissa L.pt
unicamp.author.externalReis, Felippe H. Z.pt
unicamp.author.externalCardoso, Fernanda C.pt
unicamp.author.externalPrado, Ieda M. R.pt
unicamp.author.externalUyemura, Sergio A.pt
unicamp.author.externalCurti, Carlospt
unicamp.author.externalAlberici, Luciane C.pt
dc.subjectObesitypt_BR
dc.subjectEnergy metabolismpt_BR
dc.subjectCLApt_BR
dc.subjectLiverpt_BR
dc.subjectMitochondriapt_BR
dc.subjectUCPpt_BR
dc.subject.wosAMBIENT MASS-SPECTROMETRYpt_BR
dc.subject.wosSONIC-SPRAY IONIZATIONpt_BR
dc.subject.wosBROWN ADIPOSE-TISSUEpt_BR
dc.subject.wosGENE-EXPRESSIONpt_BR
dc.subject.wosENERGY-METABOLISMpt_BR
dc.subject.wosBODY-COMPOSITIONpt_BR
dc.subject.wosPPAR-ALPHApt_BR
dc.subject.wosPLASMA-LIPIDSpt_BR
dc.subject.wosLAYING HENSpt_BR
dc.subject.wosFATTY-ACIDSpt_BR
dc.description.abstractDaily intake of conjugated linoleic acid (CLA) has been shown to reduce body fat accumulation and to increase body metabolism; this latter effect has been often associated with the up-regulation of uncoupling proteins (UCPs). Here we addressed the effects of a CLA-supplemented murine diet (similar to 2 % CLA mixture, cis-9, trans-10 and trans-10, cis-12 isomers; 45 % of each isomer on alternating days) on mitochondrial energetics, UCP2 expression/activity in the liver and other associated morphological and functional parameters, in C57BL/6 mice. Diet supplementation with CLA reduced both lipid accumulation in adipose tissues and triacylglycerol plasma levels, but did not augment hepatic lipid storage. Livers of mice fed a diet supplemented with CLA showed high UCP2 mRNA levels and the isolated hepatic mitochondria showed indications of UCP activity: in the presence of guanosine diphosphate, the higher stimulation of respiration promoted by linoleic acid in mitochondria from the CLA mice was almost completely reduced to the level of the stimulation from the control mice. Despite the increased generation of reactive oxygen species through oxi-reduction reactions involving NAD(+)/NADH in the Krebs cycle, no oxidative stress was observed in the liver. In addition, in the absence of free fatty acids, basal respiration rates and the phosphorylating efficiency of mitochondria were preserved. These results indicate a beneficial and secure dose of CLA for diet supplementation in mice, which induces UCP2 overexpression and UCP activity in mitochondria while preserving the lipid composition and redox state of the liver.pt
dc.relation.ispartofJournal of Bioenergetics and Biomembranespt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisherSpringerpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationJournal of Bioenergetics and Biomembranes. Springer, v.44, n.5, p.587-596, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume44pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage587pt_BR
dc.description.lastpage596pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0145-479Xpt_BR
dc.identifier.wosidWOS:000308965000007pt_BR
dc.identifier.doi10.1007/s10863-012-9463-ypt_BR
dc.description.sponsorshipBrazilian agency: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2013-09-19T18:06:42Z
dc.date.available2016-07-01T12:52:04Z-
dc.date.accessioned2013-09-19T18:06:42Z
dc.date.accessioned2016-07-01T12:52:04Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-07-01T12:52:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2377
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2377-
dc.contributor.departmentEspectrometria
dc.contributor.unidadeIQpt
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