Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/23773
Type: Artigo de periódico
Title: Mapeamento das interações proteína-ligante através de técnicas de RMN de ¹H utilizando detecção do ligante
Title Alternative: Screening protein-ligand interactions using ¹H NMR techniques for detecting the ligand
Author: Figueiredo, Isis Martins
Marsaioli, Anita Jocelyne
Abstract: NMR is a valuable screening tool for the binding of ligands to proteins providing structural information on both protein and ligands and is thus largely applied to drug-discovery. Among the recent NMR techniques to probe weak binding protein-ligand complexes we have critically evaluated the advantages and disadvantages of STD (Saturation Transfer Difference), WaterLOGSY (Water Ligand Observation with Gradient Spectroscopy), NOE pumping and DOSY-NOESY (Diffusion-Ordered NOESY) using a mixture of BSA (bovine serum albumin) plus salicylic acid, caffeine, citric acid, adipic acid and D-glucose.
Subject: NMR
protein-ligand interactions
bovine serum albumin
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000700019
Address: http://dx.doi.org/10.1590/S0100-40422007000700019
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000700019
Date Issue: 1-Jan-2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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