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Type: Artigo de periódico
Title: Preparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrina
Title Alternative: Preperetion and physico-chemical characterization of inclusion complexes between local anesthetics and hydroxypropyl-b-cyclodextrin
Author: Moraes, Carolina Morales
Abrami, Priscila
Gonçalves, Marcos Moisés
Andréo Filho, Newton
Fernandes, Sérgio Antonio
de Paula, Eneida
Fraceto, Leonardo Fernandes
Abstract: S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl beta-cyclodextrin (HP-beta-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-beta-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-beta-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.
Subject: S(-) Bupivacaine
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000400005
Date Issue: 1-Aug-2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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