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Type: Artigo de periódico
Title: Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals
Author: Vila, Marta Maria Duarte Carvalho
Oliveira, Robson Machado de
Gonçalves, Marcos Moisés
Tubino, Matthieu
Abstract: Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.
Subject: antibiotic
quantitative analysis
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000200029
Date Issue: 1-Apr-2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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