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Type: Artigo de periódico
Title: Cromatografia em leito móvel simulado na produção de substâncias enantiomericamente puras ou enriquecidas em larga escala
Title Alternative: Simulated moving bed chromatography in the production of enantiomerically pure or enriched compounds in large scale
Author: Silva Junior, Ivanildo José da
Veredas, Vinícius de
Santos, Marco Antônio Garcia dos
Santana, Cesar Costapinto
Carpes, Marcos José Souza
Correia, Carlos Roque Duarte
Abstract: There is great interest nowadays in the use of preparative liquid chromatography as an effective tool for the production of enantiomerically pure, or enriched, compounds for the pharmaceutical industry. To make the chromatographic process economically attractive, attention is now focused on the choice of the chromatographic operating mode to minimize eluent consumption and to maximize productivity. Among the alternatives to the traditional batch chromatography, attention is now shifting towards simulated moving bed (SMB) technologies and a review covering the latest developments in this area seems timely. Several aspects of this important analytical technique are presented and details concerning the SMB technology for process optimization are outlined.
Subject: enantiomer separations
chiral stationary phases
liquid chromatography
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422006000500024
Date Issue: 1-Oct-2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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