Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/23647
Type: Artigo de periódico
Title: Ácidos siálicos: da compreensão do seu envolvimento em processos biológicos ao desenvolvimento de fármacos contra o agente etiológico da gripe
Title Alternative: Sialic acids: from the comprehension of their involvement in biological processes to antiinfluenza drug design
Author: Fátima, Ângelo de
Baptistella, Lúcia Helena Brito
Pilli, Ronaldo Aloise
Modolo, Luzia Valentina
Abstract: Sialic acids are nine-carbon carbohydrates that occur widely in nature and occupy the terminal portions of some glycoproteins and glycolipids of cell membranes. These carbohydrates are closely involved in cell-cell interactions and in processes such as microbial infection, inflammation, etc. Studies on the participation of sialic acids in biological processes have provided comprehension about their role in the infection by the influenza virus, the causal agent of flu. In this article, we present an overview of the importance of sialic acids in the influenza virus infection and how the knowledge of their involvement in this process has allowed the development of selective and efficient drugs against the virus.
Subject: sialic acid
flu and antiinfluenza drugs
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422005000200023
Address: http://dx.doi.org/10.1590/S0100-40422005000200023
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200023
Date Issue: 1-Mar-2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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