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Type: Artigo de periódico
Title: Validação de modelos de calibração multivariada: uma aplicação na determinação de pureza polimórfica de carbamazepina por espectroscopia no infravermelho próximo
Title Alternative: Validation of models of multivariate calibration: an application in the determination of polymorphic purity of carbamazepine by near infrared spectroscopy
Author: Braga, Jez Willian B.
Poppi, Ronei Jesus
Abstract: The application of analytical procedures based on multivariate calibration models has been limited in several areas due to requirements of validation and certification of the model. Procedures for validation are presented based on the determination of figures of merit, such as precision (mean, repeatability, intermediate), accuracy, sensitivity, analytical sensitivity, selectivity, signal-to-noise ratio and confidence intervals for PLS models. An example is discussed of a model for polymorphic purity control of carbamazepine by NIR diffuse reflectance spectroscopy. The results show that multivariate calibration models can be validated to fulfill the requirements imposed by industry and standardization agencies.
Subject: validation
multivariate calibration
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422004000600027
Date Issue: 1-Dec-2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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